Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal
epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the …

Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition
leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular …

Pterygia are common ocular surface lesions thought to originate from limbal stem cells
altered by chronic UV exposure. Traditionally regarded as a degenerative condition …

Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of
substrate compliance in live tissues has not been accomplished to date. Here we propose …

The cornea is a tough transparent tissue admitting and focusing light in the eye. More than
90% of the cornea is stroma, a highly organized, transparent connective tissue maintained …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

Telocytes (TC s) are a distinct type of interstitial cells characterized by a small cell body and
extremely long and thin telopodes (Tps). The presence of TC s has been documented in …

A specialized microenvironment or niche, which regulates maintenance, self-renewal,
activation, and proliferation of stem cells by external signals, is one of the key prerequisites …

A strong cohort of evidence exists that supports the localisation of corneal stem cells at the
limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling …

The corneal stroma contains a population of mesenchymal cells subjacent to the limbal
basement membrane with characteristics of adult stem cells. These 'niche cells' support …