Transcription of eukaryotic protein-coding genes commences with the assembly of a
conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general …

Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

Transcription regulation occurs frequently through promoter-associated pausing of RNA
polymerase II (Pol II). We developed a precision nuclear run-on and sequencing (PRO-seq) …

There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …

Histone modifications regulate chromatin-dependent processes, yet the mechanisms by
which they contribute to specific outcomes remain unclear. H3K4me3 is a prominent histone …

Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …

The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR)
retrotransposons, begins with transcription by RNA polymerase II followed by reverse …

Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

Agriculture production faces many abiotic stresses, mainly drought, salinity, low and high
temperature. These abiotic stresses inhibit plants' genetic potential, which is the cause of …