The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …

The ichthyoses are a large, heterogeneous group of skin cornification disorders. They can
be inherited or acquired, and result in defective keratinocyte differentiation and abnormal …

The overall diagnostic yield of massively parallel sequencing–based tests in patients with
chronic kidney disease (CKD) is 30% for paediatric cases and 6–30% for adult cases. These …

Claudins, a group of membrane proteins involved in the formation of tight junctions, are
mainly found in endothelial or epithelial cells. These proteins have attracted much attention …

The paracellular passage of ions and small molecules across epithelia is controlled by tight
junctions, complex meshworks of claudin polymers that form tight seals between …

Tight junction (TJ) is a “zippering up” junction structure located at the uppermost portion of
adjacent epithelial/endothelial cells in organs and tissues. TJs maintain the relative stability …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

The genetic spectrum of Gitelman(-like) syndromes : Current Opinion in Nephrology and
Hypertension The genetic spectrum of Gitelman(-like) syndromes : Current Opinion in …

Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. We
performed a large genome-wide association study (GWAS) meta-analysis for KSD to date …

The kidney tubules provide homeostasis by maintaining the external milieu that is critical for
proper cellular function. Without homeostasis, there would be no heartbeat, no muscle …