Surfactant and the adult respiratory distress syndrome

JF Lewis, AH Jobe - American Review of Respiratory Disease, 1993 - atsjournals.org
In 1967, Ashbaugh and associates (1) described the development of acute respiratory
failure in 12 patients with tachypnea, hypoxemia, and a loss of lung compliance who did not …

Oxygen toxicity in the neonatal period

OLAD SAUGSTAD - Acta Paediatrica, 1990 - Wiley Online Library
Oxygen is toxic because it produces oxygen radicals. One important oxygen radical
generating system is hypoxanthine‐xanthine oxidase. Hypoxic newborn babies who have …

[图书][B] Lung surfactants: basic science and clinical applications

RH Notter - 2000 - api.taylorfrancis.com
Integrating basic and clinical research on the biophysical and physiological functions of
pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on …

A biophysical mechanism by which plasma proteins inhibit lung surfactant activity

BA Holm, G Enhorning, RH Notter - Chemistry and Physics of Lipids, 1988 - Elsevier
These in vitro experiments study a potential mechanism by which plasma proteins, found in
the alveoli during pulmonary edema and hemorrhage, may act to inhibit the surface activity …

Pulmonary surfactant-associated protein A enhances the surface activity of lipid extract surfactant and reverses inhibition by blood proteins in vitro

AM Cockshutt, J Weitz, F Possmayer - Biochemistry, 1990 - ACS Publications
Revised Manuscript Received May 22, 1990 abstract: Although a monolayer of
dipalmitoylphosphatidylcholine, the major component of pulmonary surfactant, is thought to …

Surfactant treatment of full-term newborns with respiratory failure

RL Auten, RH Notter, JW Kendig, JM Davis… - …, 1991 - publications.aap.org
Surfactant inactivation has been shown to be a significant factor in animal models of lung
injury and may also be important in some forms of respiratory failure in full-term newborns …

Carbon monoxide attenuates aeroallergen-induced inflammation in mice

JT Chapman, LE Otterbein, JA Elias… - American Journal of …, 2001 - journals.physiology.org
Carbon monoxide (CO) generated by catalysis of heme by heme oxygenase is increased in
the exhaled air of asthmatic patients. Based on recent studies demonstrating that asthma is …

Optimizing alveolar expansion prolongs the effectiveness of exogenous surfactant therapy in the adult rabbit

AB Froese, PR Mcculloch, M Sugiura… - American Review of …, 1993 - atsjournals.org
METHODS Forty-two New Zealand white rabbits weighing 2.78±0.05 kg (mean±SEM) were
anaesthetized intramuscularly with 35 mg/kg ketamine and 5 mg/kg xylazine. Anesthesia …

Keratinocyte growth factor reduces lung damage due to acid instillation in rats.

T Yano, RR Deterding, WS Simonet… - American journal of …, 1996 - atsjournals.org
Acid aspiration is a serious complication of anesthesia and other forms of unconsciousness
that can result in the adult respiratory distress syndrome (ARDS), which continues to have a …

C-reactive protein and lung diseases

M Agassandian, GV Shurin, Y Ma, MR Shurin - The international journal of …, 2014 - Elsevier
Abstract C-reactive protein (CRP), a member of the pentraxin family of plasma proteins, is
one of the most distinctive acute phase reactants. In response to inflammation, cell damage …