Biopharmaceutical and pharmacokinetic aspects of nanocarrier-mediated oral delivery of poorly soluble drugs
Many new chemical entities have limited water solubility and therefore show low and/or
variable oral bioavailability. Among the various strategies to overcome this challenge …
variable oral bioavailability. Among the various strategies to overcome this challenge …
Nanotechnology of tyrosine kinase inhibitors in cancer therapy: A perspective
E Russo, A Spallarossa, B Tasso, C Villa… - International Journal of …, 2021 - mdpi.com
Nanotechnology is an important application in modern cancer therapy. In comparison with
conventional drug formulations, nanoparticles ensure better penetration into the tumor mass …
conventional drug formulations, nanoparticles ensure better penetration into the tumor mass …
Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry
In dental practice, local anesthesia causes pain, fear, and stress, and is frequently the
reason that patients abandon treatment. Topical anesthetics are applied in order to minimize …
reason that patients abandon treatment. Topical anesthetics are applied in order to minimize …
Novel imatinib-loaded silver nanoparticles for enhanced apoptosis of human breast cancer MCF-7 cells
SA Sadat Shandiz, M Shafiee Ardestani… - Artificial cells …, 2017 - Taylor & Francis
In the current study, in vitro biological feature of imatinib-loaded silver nanoparticles (IMAB-
AgNPs) on human breast cancer cell line was investigated. The formation of synthesized …
AgNPs) on human breast cancer cell line was investigated. The formation of synthesized …
QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic targeting: evaluation using chylomicron flow blocking approach
N Rangaraj, SR Pailla, S Shah, S Prajapati… - Drug delivery and …, 2020 - Springer
Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL)
and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high …
and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high …
Effects of formulation variables on the particle size and drug encapsulation of imatinib-loaded solid lipid nanoparticles
Imatinib (IMT), an anticancer agent, inhibits receptor tyrosine kinases and is characterized
by poor aqueous solubility, extensive first-pass metabolism, and rapid clearance. The aims …
by poor aqueous solubility, extensive first-pass metabolism, and rapid clearance. The aims …
Hyaluronic acid-capped compact silica-supported mesoporous titania nanoparticles for ligand-directed delivery of doxorubicin
Mesoporous titania nanoparticles (MTN), owing to their high surface area to volume ratio
and tunable pore sizes, appear capable of delivering sizable amounts of drug payloads, and …
and tunable pore sizes, appear capable of delivering sizable amounts of drug payloads, and …
Lipid-associated oral delivery: Mechanisms and analysis of oral absorption enhancement
O Rezhdo, L Speciner, R Carrier - Journal of Controlled Release, 2016 - Elsevier
The majority of newly discovered oral drugs are poorly water soluble, and co-administration
with lipids has proven effective in significantly enhancing bioavailability of some compounds …
with lipids has proven effective in significantly enhancing bioavailability of some compounds …
PEGylated polyaminoacid-capped mesoporous silica nanoparticles for mitochondria-targeted delivery of celastrol in solid tumors
The major goal of cancer chemotherapy is to maximize the therapeutic efficacy of anticancer
drugs, while minimizing their associated side effects. Celastrol (CST), which is extracted …
drugs, while minimizing their associated side effects. Celastrol (CST), which is extracted …
Development of bioactive PEGylated nanostructured platforms for sequential delivery of doxorubicin and imatinib to overcome drug resistance in metastatic tumors
Metastasis of cancers accounts for almost all cancer-related deaths. In this study, we report a
PEGylated nanostructured platform for coadministration of doxorubicin (DOX) and imatinib …
PEGylated nanostructured platform for coadministration of doxorubicin (DOX) and imatinib …