Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …

Androgen receptor (AR) is expressed in 90% of estrogen receptor alpha–positive (ER+)
breast tumors, but its role in tumor growth and progression remains controversial. Use of two …

Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

The lysine demethylase 3A (KDM3A, JMJD1A or JHDM2A) controls transcriptional networks
in a variety of biological processes such as spermatogenesis, metabolism, stem cell activity …

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …

Background & Aims The histone lysine demethylase 3A (KDM3A) demethylates H3K9me1
and H3K9Me2 to increase gene transcription and is upregulated in tumors, including …

High aerobic glycolysis not only provides energy to cancer cells, but also supports their
anabolic growth. JMJD1A, a histone demethylase that specifically demethylates …