The Arabs in general are genetically diverse. Major factors that contributed to their diversity
include the migrations of Semitic tribes from the Arabian Peninsula, the Islamic expansion in …

Cystic fibrosis (CF) is a lethal, monogenic disorder that affects multiple organ systems of the
body. The incidence has been described before in the Middle East to be 1 in 2000 to 1 in …

The combination therapies ORKAMBITM and TRIKAFTATM are approved for people who
have the F508del mutation on at least one allele. In this study we examine the effects of …

Cystic fibrosis (CF) was considered to be non‐existent in Indian subcontinent. Reports in last
one decade have suggested that cystic fibrosis occurs in India but its precise magnitude is …

ABSTRACT BACKGROUND: Cystic fibrosis (CF) occurs in populations in Saudi Arabia and
the Gulf area. Approximately 2000 known variants have been identified for the CF …

Abstract Background The c. 3700A> G mutation, a rare cystic fibrosis (CF)-causing CFTR
mutation found mainly in the Middle East, produces full-length transcript encoding a …

BACKGROUND: Cystic fibrosis (CF) is the most common autosomal recessive disease in
Caucasians; it is however, considered to be rare in the Arab populations. Reports of the …

Objective: The objective of the study was to describe the frequency of MDR-PA recovered
from the lower respiratory samples of pediatric and adult CF patients, and its antibiotic …

Purpose: The purpose of this study was to determine the molecular consequences of the
variant c. 3700 A> G in the cystic fibrosis transmembrane conductance regulator (CFTR) …

Background Genome sequencing of large biobanks from under-represented ancestries
provides a valuable resource for the interrogation of Mendelian disease burden at world …