HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
J Dehn, S Spellman, CK Hurley… - Blood, The Journal …, 2019 - ashpublications.org
Allogeneic hematopoietic cell transplantation involves consideration of both donor and
recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution …
recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution …
A large peptidome dataset improves HLA class I epitope prediction across most of the human population
Prediction of HLA epitopes is important for the development of cancer immunotherapies and
vaccines. However, current prediction algorithms have limited predictive power, in part …
vaccines. However, current prediction algorithms have limited predictive power, in part …
A transformer-based model to predict peptide–HLA class I binding and optimize mutated peptides for vaccine design
Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to
specialized immune cells, then initiate an immune response. Computational prediction of the …
specialized immune cells, then initiate an immune response. Computational prediction of the …
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning
autoimmune and infectious diseases, transplantation and cancer. While coding variation in …
autoimmune and infectious diseases, transplantation and cancer. While coding variation in …
[HTML][HTML] The dual role of HLA-C in tolerance and immunity at the maternal-fetal interface
H Papúchová, TB Meissner, Q Li… - Frontiers in …, 2019 - frontiersin.org
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens
and remain competent to respond to infections both systemically and in placental tissues …
and remain competent to respond to infections both systemically and in placental tissues …
Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in …
We report detailed peptide‐binding affinities between 438 HLA Class I and Class II proteins
and complete proteomes of seven pandemic human viruses, including coronaviruses …
and complete proteomes of seven pandemic human viruses, including coronaviruses …
Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity
WS DeWitt III, A Smith, G Schoch, JA Hansen… - Elife, 2018 - elifesciences.org
The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic
formation of immunological memory. Statistical analysis of repertoire sequencing data has …
formation of immunological memory. Statistical analysis of repertoire sequencing data has …
Generalists and specialists: a new view of how MHC class I molecules fight infectious pathogens
J Kaufman - Trends in Immunology, 2018 - cell.com
In comparison with the major histocompatibility complexes (MHCs) of typical mammals, the
chicken MHC is simple and compact with a single dominantly expressed class I molecule …
chicken MHC is simple and compact with a single dominantly expressed class I molecule …
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D
Complete cancer regression occurs in a subset of patients following adoptive T cell therapy
(ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs). However, the low success …
(ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs). However, the low success …