This document is an update of the British Sarcoma Group guidelines (2016) and provides a
reference standard for the clinical care of UK patients with primary malignant bone tumours …

Radiomics is the extraction of predefined mathematic features from medical images for
predicting variables of clinical interest. Recent research has demonstrated that radiomics …

The advent of dose intensified interval compressed therapy has improved event-free survival
for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a …

PURPOSE The utility of circulating tumor DNA (ctDNA) analyses has not been established in
the risk stratification of Wilms tumor (WT). We evaluated the detection of ctDNA and selected …

Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with
potential applications during all stages of patient care, from diagnosis to long-term follow-up …

PURPOSE Novel biomarkers are needed to differentiate outcomes in intermediate-risk
rhabdomyosarcoma (IR RMS). We sought to evaluate strategies for identifying circulating …

Pediatric tumors share few recurrent mutations and are instead characterized by copy
number alterations (CNAs). The cell-free DNA (cfDNA) is a prominent source for the …

Background Ewing sarcoma (EWS) is an aggressive sarcoma with few treatment options for
patients with relapsed disease. Cyclin‐dependent kinase 4 (CDK4) is a genomic …

Purpose: Treatment options for recurrent or refractory Ewing's sarcoma (ES) are limited. Vigil
is a novel autologous tumor cell therapy expressing bi-shRNA furin/GMCSF plasmid, which …

Background Detection of circulating tumor-derived material (cTM) in the peripheral blood
(PB) of cancer patients has been shown to be useful in early diagnosis, prediction of …