Background Cancer is the most common cause of death and is still a serious public health
problem. Alkaloids, a class of bioactive compounds widely diffused in plants, especially …

Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk
factors including hormones like insulin and insulin like growth factors (eg, IGF-1) have been …

In this study, we report the synthesis of twenty new acridine–thiosemicarbazone derivatives
and their antiproliferative activities. Mechanisms of action such as the inhibition of …

Cancer and diabetes mellitus are served as typical life-threatening diseases with common
risk factors. Developing therapeutic measures in cancers and diabetes have aroused …

Annona muricata L. has been used traditionally in Indonesia to treat disease. Phytochemical
studies on the alkaloid fractions from the root of Annona muricata L. from Malang-Indonesia …

Piplartine (piperlongumine) is a plant-derived compound found in some Piper species that
became a novel potential antineoplastic agent. In the present study, we synthesized a novel …

Colorectal cancer (CRC) is one of the leading causes of mortality among men and women.
Chemo‑resistance, adverse effects and disease recurrence are major challenges in the …

The overexpression of lncRNA HOTAIR can result in cancer progression through
upregulation of the Akt signaling pathway. We aimed to evaluate the anticancer effects of …

Abstract Guatteria megalophylla Diels (Annonaceae) is an 8− 10 m tall tree that grows near
streams and is widely spread throughout Colombian, Ecuadorian, Peruvian, Brazilian and …

Croton matourensis Aubl.(synonym Croton lanjouwensis Jabl.), popularly known as “orelha
de burro”,“maravuvuia”, and/or “sangrad'água”, is a medicinal plant used in Brazilian folk …