Sex differences in energy metabolism: natural selection, mechanisms and consequences

F Mauvais-Jarvis - Nature Reviews Nephrology, 2024 - nature.com
Metabolic homeostasis operates differently in men and women. This sex asymmetry is the
result of evolutionary adaptations that enable women to resist loss of energy stores and …

Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1

X Lu, L Kuai, F Huang, J Jiang, J Song, Y Liu… - Nature …, 2023 - nature.com
Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which
is suffered by approximately 3% of the world population. The overexpression of reactive …

The impact of chromosomal sex on cardiometabolic health and disease

CB Wiese, R Avetisyan, K Reue - Trends in Endocrinology & Metabolism, 2023 - cell.com
Many aspects of metabolism are sex-biased, from gene expression in metabolic tissues to
the prevalence and presentation of cardiometabolic diseases. The influence of hormones …

Sex differences in cardiovascular disease and dysregulation in Down syndrome

ML Bates, A Vasileva, LDM Flores… - American Journal …, 2023 - journals.physiology.org
This meta-analysis, which consisted of a scoping review and retrospective medical record
review, is focused on potential sex differences in cardiovascular diseases in patients with …

Sex differences in white adipose tissue expansion: emerging molecular mechanisms

ST Bond, AC Calkin, BG Drew - Clinical Science, 2021 - portlandpress.com
The escalating prevalence of individuals becoming overweight and obese is a rapidly rising
global health problem, placing an enormous burden on health and economic systems …

[HTML][HTML] G protein–coupled estrogen receptor 1 ameliorates nonalcoholic steatohepatitis through targeting AMPK-dependent signaling

L Li, Y Yao, Y Wang, J Cao, Z Jiang, Y Yang… - Journal of Biological …, 2024 - ASBMB
Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH),
has emerged as a prevalent cause of liver cirrhosis and hepatocellular carcinoma, posing …

Resveratrol protects against postmenopausal atherosclerosis progression through reducing PCSK9 expression via the regulation of the ERα-mediated signaling …

Y Jing, T Hu, J Yuan, Z Liu, M Tao, M Ou… - Biochemical …, 2023 - Elsevier
Elevated circulating proprotein convertase subtilisin/kexin 9 (PCSK9) levels are an important
contributor to postmenopausal atherosclerosis (AS). We have previously reported that …

AS160 expression, but not AS160 Serine‐588, Threonine‐642, and Serine‐704 phosphorylation, is essential for elevated insulin‐stimulated glucose uptake by …

H Wang, A Zheng, EB Arias, SE Kwak, X Pan… - The FASEB …, 2023 - Wiley Online Library
One exercise session can increase subsequent insulin‐stimulated glucose uptake (ISGU) by
skeletal muscle in both sexes. We recently found that muscle expression and …

Chemistry of Bairui granules and its mechanisms in the protective effect against methotrexate-induced liver injury

L Li, J Ju, X Zhuang, S Li, R Ma, J Li, M Ding, C Ma… - Phytomedicine, 2024 - Elsevier
Background Bairui granules (BRKL), a traditional Chinese medicine preparation, possess a
range of pharmacological effects. However, its impact on methotrexate (MTX)-induced liver …

[HTML][HTML] Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex

A Moreira-Pais, R Vitorino, C Sousa-Mendes… - Free Radical Biology …, 2024 - Elsevier
Sarcopenia is associated with reduced quality of life and premature mortality. The sex
disparities in the processes underlying sarcopenia pathogenesis, which include …