Phagocytosis, a critical early event in the microbicidal response of neutrophils, is now
appreciated to serve multiple functions in a variety of cell types. Professional phagocytes …

Macrophages reside in virtually every organ. First arising during embryogenesis,
macrophages replenish themselves in the adult through a combination of self-renewal and …

PURPOSE To evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4
(5F9), a humanized IgG4 antibody that targets CD47 to enable phagocytosis. PATIENTS …

Phagoptosis, also called primary phagocytosis, is a recently recognised form of cell death
caused by phagocytosis of viable cells, resulting in their destruction. It is provoked by …

CD47 on erythrocytes inhibits phagocytosis through interaction with the inhibitory
immunoreceptor SIRPα expressed by macrophages. Thus, the CD47-SIRPα interaction …

CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-
recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular …

The spleen is one of the major immunological sites for maintaining blood homeostasis.
Previous studies showed that heterogeneous splenic macrophage populations contribute in …

Interactions between cells and their surroundings are important for proper function and
homeostasis in a multicellular organism. These interactions can either be established …

Pulmonary surfactant has two crucial roles in respiratory function; first, as a biophysical entity
it reduces surface tension at the air water interface, facilitating gas exchange and alveolar …

The acute-phase response is triggered by the presence of infectious agents and danger
signals which indicate hazards for the integrity of the mammalian body. One central feature …