Pontén F, Schwenk JM, Asplund A, Edqvist P‐HD (Uppsala University, Uppsala; and KTH–
Royal Institute of Technology, Stockholm; Sweden). The Human Protein Atlas as a proteomic …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

Using single transcription factors to reprogram cells could produce important insights into
the epigenetic mechanisms that direct normal differentiation, or counter inappropriate …

The Pax6 transcription factor is crucial for endocrine cell differentiation and function. Indeed,
mutations of Pax6 are associated with a diabetic phenotype and a drastic decrease of …

Pax6 is a highly conserved transcription factor among vertebrates and is important in various
aspects of the central nervous system development. However, the gene regulatory circuitry …

The relentless nature and increasing prevalence of human pancreatic diseases, in
particular, diabetes mellitus and adenocarcinoma, has motivated further understanding of …

Many studies have highlighted the role of dysregulated glucagon secretion in the etiology of
hyperglycemia and diabetes. Accordingly, understanding the mechanisms underlying …

The transcription factor Pax6 is a developmental regulator with a crucial role in development
of the eye, brain, and olfactory system. Pax6 is also required for correct development of the …

Most organisms, including humans, have developed an intrinsic system of circadian
oscillators, allowing the anticipation of events related to the rotation of Earth around its own …