The medial prefrontal cortex (mPFC) is important for social behavior, but the mechanisms by
which mPFC neurons code real-time social exploration remain largely unknown. Here we …

Schizophrenia is a psychiatric disorder characterized by hallucinations, anhedonia,
disordered thinking, and cognitive impairments. Both genetic and environmental factors …

A central question related to virtually all social decisions is how animals integrate sex-
specific cues from conspecifics. Using microendoscopic calcium imaging in mice, we find …

Depression is more prevalent among adolescents than adults, but the underlying
mechanisms remain largely unknown. Using a subthreshold chronic stress model, here we …

Early life stress is thought to be a risk factor for emotional disorders, particularly depression
and anxiety. Although the excitation/inhibition (E/I) imbalance has been implicated in …

Neuronal atrophy and alterations of synaptic structure and function in the medial prefrontal
cortex (mPFC) have been implicated in the pathogenesis of depression, but the underlying …

Tropomyosin receptor kinase B (TrkB) signaling plays a pivotal role in dendritic growth and
dendritic spine formation to promote learning and memory. The activity-dependent release …

Mitochondrial movement in neurons is finely regulated to meet the local demand for energy
and calcium buffering. Elaborate transport machinery including motor complexes is required …

Both clinical and animal studies showed that the impaired functions of the orbitofrontal
cortex (OFC) underlie the compulsive drug-seeking behavior of drug addiction. However, the …

Object Early‐life neglect has irreversible emotional effects on the central nervous system. In
this work, we aimed to elucidate distinct functional neural changes in medial prefrontal …