The gut microbiome of laboratory mice: considerations and best practices for translational research
AC Ericsson, CL Franklin - Mammalian Genome, 2021 - Springer
Just as the gut microbiota (GM) is now recognized as an integral mediator of environmental
influences on human physiology, susceptibility to disease, and response to pharmacological …
influences on human physiology, susceptibility to disease, and response to pharmacological …
Longitudinal analysis of the microbiome and metabolome in the 5xfAD mouse model of Alzheimer's disease
SJB Dunham, KA McNair, ED Adams… - MBio, 2022 - Am Soc Microbiol
Recent reports implicate gut microbiome dysbiosis in the onset and progression of
Alzheimer's disease (AD), yet studies involving model animals overwhelmingly omit the …
Alzheimer's disease (AD), yet studies involving model animals overwhelmingly omit the …
A host of issues: pseudoreplication in host–microbiota studies
H McKinnon Reish, L Dewey… - Applied and …, 2024 - journals.asm.org
Pseudoreplication compromises the validity of research by treating non-independent
samples as independent replicates. This review examines the prevalence of …
samples as independent replicates. This review examines the prevalence of …
Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice
Purpose Probiotics and prebiotics are commonly used to improve the gut microbiota. Since
prebiotics can support the growth of probiotics, co-administration of these is called …
prebiotics can support the growth of probiotics, co-administration of these is called …
Shared environment and genetics shape the gut microbiome after infant adoption
The composition of the human gut microbiome is highly variable, and this variation has been
repeatedly tied to variation in human health. However, the sources of microbial variation …
repeatedly tied to variation in human health. However, the sources of microbial variation …
Microbiome alterations are associated with apolipoprotein E mutation in Octodon degus and humans with Alzheimer's disease
Gut microbiome dysbiosis is linked to many neurological disorders including Alzheimer's
disease (AD). A major risk factor for AD is polymorphism in the apolipoprotein E (APOE) …
disease (AD). A major risk factor for AD is polymorphism in the apolipoprotein E (APOE) …
Eosinophils respond to, but are not essential for control of an acute Salmonella enterica serovar Typhimurium infection in mice
RD FitzPatrick, JR Noone, RA Cartwright… - Infection and …, 2024 - journals.asm.org
Eosinophils are a highly abundant cell type in the gastrointestinal tract during homeostatic
conditions, where they have recently been reported to take on an activated phenotype …
conditions, where they have recently been reported to take on an activated phenotype …
Dextran sodium sulfate-induced colitis alters the proportion and composition of replicating gut bacteria
ET Beauchemin, C Hunter, CF Maurice - mSphere, 2024 - journals.asm.org
The bacteria living in the human gut are essential for host health. Though the composition
and metabolism of these bacteria are well described in both healthy hosts and those with …
and metabolism of these bacteria are well described in both healthy hosts and those with …
Quality control in metagenomics data
Experiments involving metagenomics data are become increasingly commonplace.
Processing such data requires a unique set of considerations. Quality control of …
Processing such data requires a unique set of considerations. Quality control of …
Infection and antibiotic-associated changes in the fecal microbiota of C. rodentium ϕstx2dact-infected C57BL/6 mice
S Mühlen, AK Heroven, B Elxnat, S Kahl… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Enterohemorrhagic Escherichia coli causes watery to bloody diarrhea, which may progress
to hemorrhagic colitis and hemolytic-uremic syndrome. While early studies suggested that …
to hemorrhagic colitis and hemolytic-uremic syndrome. While early studies suggested that …