Iron is the most abundant transition metal in the human body and its bioavailability is
stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to …

To fulfill their nutritional requirement for iron, bacteria utilize various iron sources which
include the host proteins transferrin and lactoferrin, heme, and low molecular weight iron …

This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

TonB-dependent transporters (TBDTs) are present in all gram-negative bacteria and
mediate energy-dependent uptake of molecules that are too scarce or large to be taken up …

Virtually all bacterial pathogens require iron to infect vertebrates. The most abundant source
of iron within vertebrates is in the form of heme as a cofactor of hemoproteins. Many …

Efficient iron acquisition is critical for an invading microbe's survival and virulence. Most of
the iron in mammals is incorporated into heme, which can be plundered by certain bacterial …

Conspectus Heme proteins have proven to be a convenient platform for the development of
designer proteins with novel functionalities. This is achieved by substituting the native iron …

Covering: 2000–2006 The ability of bacterial pathogens to obtain iron is essential for their
survival, and the expression of such virulence factors is (in part) essential for establishing …

The heme uptake systems by which bacterial pathogens acquire and utilize heme have
recently been described. Such systems may utilize heme directly from the host's …

The extreme limitation of free iron has driven various pathogens to acquire iron from the host
in the form of heme. Specifically, several Gram-negative pathogens secrete a heme binding …