The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …

Retroviruses integrate their reverse transcribed genomes into host cell chromosomes as an
obligate step in virus replication. The nuclear envelope separates the chromosomes from …

HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving
functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we …

Transportin 3 (Tnpo3, Transportin-SR2) is implicated in nuclear import of splicing factors and
HIV-1 replication. Herein, we show that the majority of cellular Tnpo3 binding partners …

Background Despite intensive investigation the mechanism by which HIV-1 reaches the host
cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was …

The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral
infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a …

Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced GTPase that inhibits
human immunodeficiency virus-1 (HIV-1) infection by preventing nuclear import of the viral …

Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used
Bayesian and frequentist approaches to model the IRF5–TNPO3 locus association, now …

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral
agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we …

RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to
facilitate their replication. HIV-1, one of the most well-studied retroviruses, is not an …