A network-biology perspective of microRNA function and dysfunction in cancer
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …
and consequently have roles in many pathologies, including cancer. These small non …
Bioinformatic tools for microRNA dissection
Recently, microRNAs (miRNAs) have emerged as important elements of gene regulatory
networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼ 22-nt long) that …
networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼ 22-nt long) that …
iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data
Background RNA-seq is widely used for transcriptomic profiling, but the bioinformatics
analysis of resultant data can be time-consuming and challenging, especially for biologists …
analysis of resultant data can be time-consuming and challenging, especially for biologists …
TransmiR v2. 0: an updated transcription factor-microRNA regulation database
Z Tong, Q Cui, J Wang, Y Zhou - Nucleic acids research, 2019 - academic.oup.com
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and
play vital roles in various biological processes. It has been reported that aberrant regulation …
play vital roles in various biological processes. It has been reported that aberrant regulation …
ChIPBase v2. 0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data
The abnormal transcriptional regulation of non-coding RNAs (ncRNAs) and protein-coding
genes (PCGs) is contributed to various biological processes and linked with human …
genes (PCGs) is contributed to various biological processes and linked with human …
ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …
Transcription factor and microRNA co-regulatory loops: important regulatory motifs in biological processes and diseases
Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate target gene
expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs). These …
expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs). These …
Identification of microRNA-regulated gene networks by expression analysis of target genes
MicroRNAs (miRNAs) and transcription factors control eukaryotic cell proliferation,
differentiation, and metabolism through their specific gene regulatory networks. However …
differentiation, and metabolism through their specific gene regulatory networks. However …
Combinatorial targeting by microRNAs co-ordinates post-transcriptional control of EMT
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression,
functioning in part by facilitating the degradation of target mRNAs. They have an established …
functioning in part by facilitating the degradation of target mRNAs. They have an established …
MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy.
The understanding of its gene expression regulation and molecular mechanisms still …
The understanding of its gene expression regulation and molecular mechanisms still …