Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Simple Summary Cisplatin is successfully used for the treatment of various solid cancers.
Unfortunately, it shows no activity in colorectal cancer. The resistance phenotype of …

CK2 (casein kinase 2) is a very pleiotropic serine/threonine protein kinase whose
abnormally high constitutive activity has often been correlated to pathological conditions …

cis-Diamminedichloroplatinum (II)(cisplatin) is among the most active antitumour agent used
in human chemotherapy. The purpose of this review is to give an insight in several …

The tumour suppressor HIPK2 is an important regulator of cell death induced by DNA
damage, but how its activity is regulated remains largely unclear. Here we demonstrate that …

We established previously that X-linked inhibitor of apoptosis protein (Xiap) is a determinant
of cisplatin (CDDP) resistance in human ovarian cancer cells and that down-regulation of …

In response to DNA damage, p53 induces either cell-cycle arrest or apoptosis by differential
transcription of several target genes and through transcription-independent apoptotic …

The p53 protein is the most studied tumor suppressor and the p53 pathway has been shown
to mediate cellular stress responses that are disrupted when cancer develops. After DNA …

Oxygen deprivation (hypoxia) results in reprogrammed gene expression patterns that induce
multifaceted cellular responses. Here we identify a regulated interaction between the …