Use of computational fluid dynamics deposition modeling in respiratory drug delivery
Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
Devices for improved delivery of nebulized pharmaceutical aerosols to the lungs
Nebulizers have a number of advantages for the delivery of inhaled pharmaceutical
aerosols, including the use of aqueous formulations and the ability to deliver process …
aerosols, including the use of aqueous formulations and the ability to deliver process …
Investigation of fugitive aerosols released into the environment during high-flow therapy
JA McGrath, C O'Toole, G Bennett, M Joyce, MA Byrne… - Pharmaceutics, 2019 - mdpi.com
Background: Nebulised medical aerosols are designed to deliver drugs to the lungs to aid in
the treatment of respiratory diseases. However, an unintended consequence is the potential …
the treatment of respiratory diseases. However, an unintended consequence is the potential …
Evaluation of the polyhedral mesh style for predicting aerosol deposition in representative models of the conducting airways
ML Thomas, PW Longest - Journal of aerosol science, 2022 - Elsevier
A critical factor affecting the accuracy of Computational Fluid Dynamic (CFD) simulations
and the time required to conduct them is construction of the computational mesh. This study …
and the time required to conduct them is construction of the computational mesh. This study …
CFD guided optimization of nose-to-lung aerosol delivery in adults: effects of inhalation waveforms and synchronized aerosol delivery
Purpose The objective of this study was to optimize nose-to-lung aerosol delivery in an adult
upper airway model using computational fluid dynamics (CFD) simulations in order to guide …
upper airway model using computational fluid dynamics (CFD) simulations in order to guide …
In vitro determination of the main effects in the design of high-flow nasal therapy systems with respect to aerosol performance
G Bennett, M Joyce, L Sweeney, R MacLoughlin - Pulmonary therapy, 2018 - Springer
Introduction The use of concurrent aerosol delivery during high-flow nasal therapy (HFNT)
may be exploited to facilitate the delivery of a variety of prescribed medications for …
may be exploited to facilitate the delivery of a variety of prescribed medications for …
Application of an inline dry powder inhaler to deliver high dose pharmaceutical aerosols during low flow nasal cannula therapy
Inline dry powder inhalers (DPIs) offer a potentially effective option to deliver high dose
inhaled medications simultaneously with mechanical ventilation. The objective of this study …
inhaled medications simultaneously with mechanical ventilation. The objective of this study …
Aerosol drug delivery during noninvasive positive pressure ventilation: Effects of intersubject variability and excipient enhanced growth
Background: Nebulized aerosol drug delivery during the administration of noninvasive
positive pressure ventilation (NPPV) is commonly implemented. While studies have shown …
positive pressure ventilation (NPPV) is commonly implemented. While studies have shown …
Septoplasty effect on the enhancement of airflow distribution and particle deposition in nasal cavity: A numerical study
The surgery outcomes after fixing nasal airway obstruction (NAO) are sometimes not
satisfactory in improving ventilations of airflow. A case study is presented in this paper with …
satisfactory in improving ventilations of airflow. A case study is presented in this paper with …
Development of a high-flow nasal cannula and pharmaceutical aerosol combination device
Background: Aerosol drug delivery to the lungs is known to be very inefficient during all
forms of noninvasive ventilation, especially when the aerosol is administered simultaneously …
forms of noninvasive ventilation, especially when the aerosol is administered simultaneously …