Therapeutic potential of plant iridoids in depression: a review

Y Kou, Z Li, T Yang, X Shen, X Wang, H Li… - Pharmaceutical …, 2022 - Taylor & Francis
Context Depression is a mental disorder characterized by low mood, reduced interest,
impaired cognitive function, and vegetative symptoms such as sleep disturbances or poor …

A review on bioactive iridoids in edible fruits–from garden to food and pharmaceutical products

D Przybylska, AZ Kucharska… - Food Reviews …, 2023 - Taylor & Francis
Iridoids are natural monoterpenoids, widely distributed in ornamental plants, herbs, and
medicinal plants, but particularly in the green parts of plants. Their significance arises from …

Loganin attenuates high glucose-induced schwann cells pyroptosis by inhibiting ROS generation and NLRP3 inflammasome activation

YC Cheng, LW Chu, JY Chen, SL Hsieh, YC Chang… - Cells, 2020 - mdpi.com
Diabetic peripheral neuropathy (DPN) is caused by hyperglycemia, which induces oxidative
stress and inflammatory responses that damage nerve tissue. Excessive generation of …

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats

S Wang, W Lv, H Zhang, Y Liu, L Li, JR Jefferson… - Geroscience, 2020 - Springer
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …

Loganin ameliorates painful diabetic neuropathy by modulating oxidative stress, inflammation and insulin sensitivity in streptozotocin-nicotinamide-induced diabetic …

YC Cheng, YM Chiu, ZK Dai, BN Wu - Cells, 2021 - mdpi.com
Loganin is an iridoid glycoside with antioxidant, anti-inflammatory, glucose-lowering
activities which may address the pathological mechanisms of painful diabetic neuropathy …

Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling

Y Chen, J Chen, M Jiang, Y Fu, Y Zhu, N Jiao, L Liu… - Life sciences, 2020 - Elsevier
Abstract Background/aims Rehmanniae Radix (RR) and Cornus officinalis (CO) are a typical
herbal pair used to treat diabetic nephropathy (DN) in clinical practice. DN can be effectively …

Examining the correlation between salivary cytokine concentrations and CRP in people experiencing social-cognitive stress

ECP Chu, A Spaska, D Monov, M Kasatkin… - Neurological …, 2023 - Taylor & Francis
Objectives The study aims to determine the relationship of migraine and chronic tension-
type headache (TTHs) with alterations in the salivary markers of inflammation.-Methods The …

Loganin improves chronic unpredictable mild stress-induced depressive-like behaviors and neurochemical dysfunction

YX Guo, CY Xia, Y Yan, Y Han, R Shi, J He… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Cornus officinalis Sieb. et Zucc., is a valuable
herb commonly used in Chinese medicine clinics. Loganin is a major iridoid glycoside …

Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

F Zhang, Y Yan, J Zhang, L Li, YW Wang… - Phytotherapy …, 2022 - Wiley Online Library
Iridoid glycosides (IGs) are found in many medicinal and edible plants, such as Gardenia
jasminoides, Cistanche tubulosa, Eucommia ulmoides, Rehmanniae Radix, Lonicera …

Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling

B Xia, J Ding, Q Li, K Zheng, J Wu, C Huang… - International journal of …, 2024 - Elsevier
Background Myocardial ischemia-reperfusion injury (MIRI) is a pathological process that
follows immediate revascularization of myocardial infarction and is characterized by …