The translation initiation step in eukaryotes is highly regulated and rate-limiting. During this
process, the 40S ribosomal subunit is usually recruited to the 5′ terminus of the mRNA. It …

During early development, apoptosis plays a major role in the ontogeny of the germ line as a
means of regulating the germ cell: Sertoli cell ratio. In the adult, apoptosis fulfils another …

PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons.
Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are …

Spermiogenesis is a long process whereby haploid spermatids derived from the meiotic
divisions of spermatocytes undergo metamorphosis into spermatozoa. It is subdivided into …

Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of
generating mature spermatozoa. The developmental processes acting on male germ cells …

Posttranscriptional status of messenger RNAs (mRNA) can be affected by many factors,
most of which are RNA‐binding proteins (RBP) that either bind mRNA in a nonspecific …

Spermatogenesis is a cell differentiation programme that allows a normally dividing diploid
cell to become haploid and to acquire the morphological characteristics required to reach …

Apoptosis plays a significant role in regulating germ cell development by removing
damaged germ cells from seminiferous tubules, thereby safeguarding the genome of a given …

SUMMARY A significant decline in human male reproductive function has been reported for
the past 20 years but the molecular mechanisms remain poorly understood. However, recent …

Cryptorchidism is the most common cause of non-obstructive azoospermia in man. In
contrast to the general belief that temperature-dependent effects on the undescended gonad …