Neuroinflammation

D Mukhara, U Oh, GN Neigh - Handbook of Clinical Neurology, 2020 - Elsevier
Neuroinflammation is implicated in contributing to a variety of neurologic and somatic
illnesses including Alzheimer's disease (AD), Parkinson's disease (PD), and depression. In …

Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects

MG Rahbardar, B Amin, S Mehri, SJ Mirnajafi-Zadeh… - Phytomedicine, 2018 - Elsevier
Background We aimed to investigate the potential prophylactic and curative effects of
rosmarinic acid, one of the main constituents of rosemary, on the neuropathic pain induced …

Ameliorative role of metformin on lipopolysaccharide-mediated liver malfunction through suppression of inflammation and oxidative stress in rats

F Beheshti, M Hosseini, Z Arab, A Asghari… - Toxin …, 2022 - Taylor & Francis
Liver is susceptible to oxidative stress and inflammation. The effect of metformin on
lipopolysaccharide (LPS)-mediated liver malfunction was investigated. Rats were grouped …

Inducible nitric oxide synthase plays a role in depression-and anxiety-like behaviors chronically induced by lipopolysaccharide in rats: Evidence from inflammation …

F Beheshti, M Hashemzehi, M Hosseini… - Behavioural brain …, 2020 - Elsevier
Objective The effects of aminoguanidine (AG) were investigated in a rat model of
lipopolysaccharide (LPS)-induced anxiety-and depression-like behaviors. Materials and …

Investigating the ameliorative effect of alpha‐mangostin on development and existing pain in a rat model of neuropathic pain

M Ghasemzadeh Rahbardar, BM Razavi… - Phytotherapy …, 2020 - Wiley Online Library
Mangosteen fruit has been used for various disorders, including pain. The effects of alpha‐
mangostin, the main component of mangosteen, on the neuropathic pain caused by chronic …

Beclin-1-mediated autophagy may be involved in the elderly cognitive and affective disorders in streptozotocin-induced diabetic mice

ZF Guan, XL Zhou, XM Zhang, Y Zhang… - Translational …, 2016 - Springer
Background Diabetes is the most common metabolic disease with many chronic
complications, and cognitive disorders are one of the common complications in patients with …

The Antidiabetic Drug Metformin Attenuated Depressive and Anxiety-like Behaviors and Oxidative Stress in the Brain in a Rodent Model of Inflammation Induced by …

FSH Kakhki, A Asghari, Z Bardaghi… - … Metabolic & Immune …, 2024 - benthamdirect.com
Background: Inflammation is considered to be a link between diabetes and central nervous
system (CNS) disorders, including depression and anxiety. Metformin is suggested to have …

Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation

F Zhang, Y Fu, X Zhou, W Pan, Y Shi, M Wang… - Journal of …, 2016 - Elsevier
Previous studies have demonstrated that lycopene possesses anti-inflammatory properties
in the central nervous system. However, the potential role and the molecular mechanisms of …

Prior maternal separation stress alters the dendritic complexity of new hippocampal neurons and neuroinflammation in response to an inflammatory stressor in …

S Nicolas, AJ McGovern, CM Hueston… - Brain, Behavior, and …, 2022 - Elsevier
Stress during critical periods of neurodevelopment is associated with an increased risk of
developing stress-related psychiatric disorders, which are more common in women than …

Protective effect against brain tissues oxidative damage as a possible mechanism for beneficial effects of L-arginine on lipopolysaccharide induced memory …

M Hosseini, A Anaeigoudari, F Beheshti… - Drug and chemical …, 2018 - Taylor & Francis
Abstract l-Arginine (LA) and nitric oxide (NO) have been suggested to have some effects on
learning, memory, brain tissues oxidative damage, and neuroinflammation. In this study …