This systematic review and meta-analysis aimed to clarify the associations between
meaning in life and physical health using random-effects models. Conceptualisation of …

Constipation is a common problem in patients with advanced cancer and a significant
source of major morbidity and distress, which is often under-appreciated [1]. Constipation is …

Background Immune checkpoint inhibitors and targeted therapies have dramatically
improved outcomes in patients with advanced melanoma, but approximately half these …

Introduction DLL3, an atypical Notch ligand, is expressed in SCLC tumors but is not
detectable in normal adult tissues. Rovalpituzumab tesirine (Rova-T) is an antibody-drug …

Immune checkpoint inhibitors have shown efficacy against metastatic triple-negative breast
cancer (mTNBC) but only for PD-L1positive disease. The randomized, placebo-controlled …

Background: Life-quality tests are the basis for assessing the condition of oncological
patients. They allow for obtaining valuable information from the patients regarding not only …

Adverse Childhood Experiences (ACEs) are associated with poor health outcomes,
underlining the significance of early identification and intervention. Currently, there is no …

PURPOSE: To update the international consensus on palliative radiotherapy endpoints for
future clinical trials in bone metastases by surveying international experts regarding …

Bone metastases represent an important complication of malignant tumours. Despite
improvement in surgical techniques and advances in systemic therapies, management of …

Context Specialized palliative care teams are increasingly providing care for the terminally
ill. However, the impact of such teams on quality of life, satisfaction with care, and economic …