Progressive multifocal leukoencephalopathy (PML) is a rare, devastating demyelinating
disease of the CNS caused by the JC virus (JCV) that occurs in patients with compromised …

Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous
system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe …

Objective Our aim was to assess the real‐world effectiveness of immune checkpoint
inhibitors for treatment of patients with progressive multifocal leukoencephalopathy (PML) …

The migration of circulating leukocytes into the central nervous system (CNS) is a key driver
of multiple sclerosis (MS) pathogenesis. The monoclonal antibody natalizumab proved that …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
caused by CNS-infiltrating leukocytes, including TH17 cells that are critical mediators of …

JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …

Treatment of PML with Nivolumab A patient with severe idiopathic lymphopenia and
progressive multifocal leukoencephalopathy had T-cell exhaustion and high expression of …

Subtyping patients into subgroups based on biotypes has emerged as a useful approach for
studying heterogeneous diseases. Understanding biotypes of HIV-associated …

Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the
central nervous system (CNS) caused by JC virus (JCV), which occurs in …

In the fifty years since the discovery of JC polyomavirus (JCPyV), the body of research
representing our collective knowledge on this virus has grown substantially. As the …