The four Janus kinase (JAK) proteins and seven signal transducer and activator of
transcription (STAT) transcription factors mediate intracellular signal transduction …

Background There is a growing armamentarium for the treatment of moderate-to-severe
ulcerative colitis. We aimed to compare the relative efficacy and safety of biologics and small …

Background There is a great unmet need for advanced therapies that provide rapid, robust,
and sustained disease control for patients with ulcerative colitis. We assessed the efficacy …

Background The global prevalence of ulcerative colitis is increasing, and induction and
maintenance of remission is a crucial therapeutic goal. We assessed the efficacy and safety …

An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …

Objectives Janus kinase inhibitors (JAKi) have been approved for use in various immune-
mediated inflammatory diseases. With five agents licensed, it was timely to summarise the …

Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease.
The Janus kinase-signal transducer and activator of transcription pathway plays a major role …

Epithelial barriers have to constantly cope with both harmless and harmful stimuli. The
epithelial barrier therefore serves as a dynamic and not static wall to safeguard its proper …

Abstract Background Gegen Qinlian decoction (GQ) is a traditional Chinese herbal
prescription that has been widely used for the treatment of bacterial dysentery and enteric …

Type 2 immunity evolved to combat helminth infections by orchestrating a combined
protective response of innate and adaptive immune cells and promotion of parasitic worm …