Targeting the renin-angiotensin-aldosterone system in fibrosis

M AlQudah, TM Hale, MP Czubryt - Matrix Biology, 2020 - Elsevier
Fibrosis is characterized by excessive deposition of extracellular matrix components such as
collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any …

Adrenal vein sampling: how to make it quick, easy, and successful

N Daunt - Radiographics, 2005 - pubs.rsna.org
Adrenal vein sampling has a reputation as a difficult procedure. However, it is being
performed more frequently at some institutions due to the realization that primary …

Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents

P Mulatero, M Stowasser, KC Loh… - The Journal of …, 2004 - academic.oup.com
Primary aldosteronism (PA) is a common form of endocrine hypertension previously
believed to account for less than 1% of hypertensive patients. Hypokalemia was considered …

Prevalence and characteristics of the metabolic syndrome in primary aldosteronism

F Fallo, F Veglio, C Bertello, N Sonino… - The Journal of …, 2006 - academic.oup.com
Context: Patients with hypertension have a high prevalence of concurrent metabolic
abnormalities, including obesity, dyslipidemia, and hyperglycemia. Clustering of these …

Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism

C Catena, GL Colussi, R Lapenna, E Nadalini… - …, 2007 - Am Heart Assoc
Exposure to excess aldosterone results in cardiac damage in hypertensive states. We
evaluated the long-term cardiac structural and functional evolution in patients with primary …

The link between adipose tissue renin-angiotensin-aldosterone system signaling and obesity-associated hypertension

MTJ Schütten, AJHM Houben, PW de Leeuw… - …, 2017 - journals.physiology.org
Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …

Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src

GE Callera, RM Touyz, RC Tostes, A Yogi, Y He… - …, 2005 - Am Heart Assoc
Increasing evidence indicates that aldosterone elicits vascular effects through nongenomic
signaling pathways. We tested the hypothesis that aldosterone induces activation of …

Extracellular matrix remodeling in atrial fibrosis: mechanisms and implications in atrial fibrillation

J Pellman, RC Lyon, F Sheikh - Journal of molecular and cellular …, 2010 - Elsevier
Atrial fibrosis has been strongly associated with the presence of heart diseases/arrhythmias,
including congestive heart failure (CHF) and atrial fibrillation (AF). Inducibility of AF as a …

Diagnosis of primary aldosteronism: from screening to subtype differentiation

P Mulatero, RG Dluhy, G Giacchetti, M Boscaro… - Trends in Endocrinology …, 2005 - cell.com
Numerous studies conducted in recent years have reported an increase in the prevalence of
primary aldosteronism (PA). This increase has arisen because of changes in our screening …

Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism

G Bernini, F Galetta, F Franzoni, M Bardini… - Journal of …, 2008 - journals.lww.com
Methods This observational study, conducted in a University Hypertension Center,
evaluated the carotid wall by 2-D ultrasonography and ultrasonic tissue characterization …