An overview on dietary polyphenols and their biopharmaceutical classification system (BCS)

F Truzzi, C Tibaldi, Y Zhang, G Dinelli… - International Journal of …, 2021 - mdpi.com
Polyphenols are natural organic compounds produced by plants, acting as antioxidants by
reacting with ROS. These compounds are widely consumed in daily diet and many studies …

Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review

S Alfei, F Turrini, S Catena, P Zunin, M Grilli… - European journal of …, 2019 - Elsevier
It is well-known that the health properties attributed to several fruits, herbs, seeds and their
processed foods/beverages are due to an important group of natural polyphenols classified …

Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson's disease: Possible involvement of ERβ/Nrf2/HO-1 signaling

T Baluchnejadmojarad, N Rabiee, S Zabihnejad… - Brain Research, 2017 - Elsevier
Parkinson's disease (PD) is a prevalent movement disorder in the elderly with progressive
loss of mesencephalic dopaminergic neurons and incapacitating motor and non-motor …

Ellagic acid protects against diabetes-associated behavioral deficits in rats: Possible involved mechanisms

Y Farbood, M Rashno, S Ghaderi, SE Khoshnam… - Life sciences, 2019 - Elsevier
Aims Diabetes mellitus (DM), a chronic metabolic disease, is associated with behavioral
deficits. It has been suggested that ellagic acid (EA), a natural polyphenol compound, has …

Metabolic fate of ellagitannins: implications for health, and research perspectives for innovative functional foods

C Garcia-Munoz, F Vaillant - Critical reviews in food science and …, 2014 - Taylor & Francis
Consumption of dietary ellagitannins (ETs) has been associated with different health
benefits. Nonetheless, ETs are not bioavailable as such and are metabolized in vivo. They …

Bioavailability and bioactivity of free ellagic acid compared to pomegranate juice

J Long, Y Guo, J Yang, SM Henning, RP Lee… - Food & function, 2019 - pubs.rsc.org
Pomegranates are an excellent source of ellagic acid (EA), ellagitannins (ETs),
anthocyanins and other phytochemicals. The health benefits of pomegranate (Pom) have …

Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action

MY Al-Nour, MM Ibrahim, T Elsaman - Current pharmacology reports, 2019 - Springer
The pharmacological activity of Acacia nilotica's phytochemical constituents was confirmed
with evidence-based studies, but the determination of exact targets that they bind and the …

Ellagic acid ameliorates learning and memory deficits in a rat model of Alzheimer's disease: an exploration of underlying mechanisms

Z Kiasalari, R Heydarifard, M Khalili, S Afshin-Majd… - …, 2017 - Springer
Rationale Alzheimer's disease (AD) is a neurodegenerative disorder with irreversible loss of
intellectual abilities. Current therapies for AD are still insufficient. Objective In this study, the …

Oral supplementation of Gordonibacter urolithinfaciens promotes ellagic acid metabolism and urolithin bioavailability in mice

Y Yang, PK Lee, HC Wong, D Zhao - Food Chemistry, 2024 - Elsevier
Ellagic acid (EA) is an abundant dietary polyphenol with multifarious health benefits but low
bioavailability. To increase its bio-efficacy, converting EA to urolithins by supplementing …

[HTML][HTML] Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis …

N Sanadgol, F Golab, Z Tashakkor, N Taki… - Pharmaceutical …, 2017 - pmc.ncbi.nlm.nih.gov
Context: Ellagic acid (EA) is a natural phenol antioxidant with various therapeutic activities.
However, the efficacy of EA has not been examined in neuropathologic conditions …