Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

Abstract SIRT1 (Sir2) is an NAD+-dependent deacetylase that plays critical roles in a broad
range of biological events, including metabolism, the immune response and ageing …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Macroautophagy, initially described as a non-selective nutrient recycling process, is
essential for the removal of multiple cellular components. In the past three decades …

Autophagy contributes to the selective degradation of liquid droplets, including the P-
Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and …

The removal of unwanted or damaged mitochondria by autophagy, a process called
mitophagy, is essential for key events in development, cellular homeostasis, tumor …

The selective clearance of organelles by autophagy is critical for the regulation of cellular
homeostasis in organisms from yeast to humans. Removal of damaged organelles clears …

Certain proteins and organelles can be selectively degraded by autophagy. Typical
substrates and receptors of selective autophagy have LC3-interacting regions (LIRs) that …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …