The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

Malignant tumor has become one of the major diseases that seriously endangers human
health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely …

Eleven previously undescribed alkaloids, including three pairs of enantiomers
nitidumalkaloids A–C, a pair of scalemic mixtures nitidumalkaloid D and three optically pure …

Hepatocellular carcinoma (HCC) incidence, as well as related mortality, has been steadily
increasing in the USA and across the globe, partly due to the lack of effective therapeutic …

Cancer metastasis occurs through local invasion of circulating tumour cells (CTCs),
intravasation, transportation to distant sites, and their extravasation followed by colonisation …

BACKGROUND Hepatocellular carcinoma (HCC) is the third leading cause of death from
malignant tumors worldwide. More than 50% of HCC cases occur in China. The prognosis …

Abstract miR-34a is significantly down-regulated in breast cancer tissues and cell lines,
which may be correlated with breast cancer multi-drug resistance (MDR). Here, we …

Reactivation of the stem cell programme in breast cancer is significantly associated with
persistent cancer progression and therapeutic failure. Breast cancer stem cells (BCSCs) are …

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality,
and despite recent advances in early diagnosis and therapeutics, HCC related morbidity …

Mortality from triple negative breast cancer (TNBC) is significantly higher in African American
(AA) women compared to White American (WA) women emphasizing ethnicity as a major …