Abstract Experts from the European Leukemia Net (ELN) working group for adult acute
lymphoblastic leukemia have identified an unmet need for guidance regarding management …

B cell acute lymphoblastic leukemia (B-ALL) arises from genetic alterations impacting B cell
progenitors, ultimately leading to clinically overt disease. Extensive collaborative efforts in …

Acute lymphoblastic leukemia (ALL) with fusions of ABL-class tyrosine kinase genes other
than BCR:: ABL1 occurs in∼ 3% of children with ALL. The tyrosine kinase genes involved in …

High-risk subtypes of B-cell acute lymphoblastic leukemia (B-ALL) are frequently associated
with aberrant activation of tyrosine kinases (TKs). These include Ph+ B-ALL driven by BCR …

Genetic alterations are the cornerstone of risk stratification in B-cell precursor acute
lymphoblastic leukemia (BCP-ALL), and their accurate identification is critical for optimal …

Abstract Background Philadelphia chromosome (Ph)–like B‐acute lymphoblastic leukemia
(B‐ALL) is a clinically significant, high‐risk genetic subtype of B‐ALL cases. There are few …

Background Previous studies have shown continuous improved overall survival (OS) up to
2015 for young adults with acute lymphoblastic leukaemia (ALL). However, recently several …

Cytogenetic analysis is mandatory at initial assessment of B-cell acute lymphoblastic
leukemia (B-ALL) due to its diagnostic and prognostic value. Results from chromosome …

Whole genome and whole transcriptome sequencing (WGTS) can accurately distinguish B-
cell acute lymphoblastic leukemia (B-ALL) genomic subtypes. However, whether this is …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) represents a
high-risk B-lineage ALL subtype characterized by adverse clinical features and poor relapse …