Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Biology is dynamic. Timescales range from frenetic sub-second ion fluxes and enzymatic
reactions to the glacial millions of years of evolutionary change. Falling somewhere in the …

The cerebral cortex is formed by diverse neurons generated sequentially from neural stem
cells (NSCs). A clock mechanism has been suggested to underlie the temporal progression …

The generation of neocortical neurons from neural progenitor cells (NPCs) is primarily
controlled by transcription factors binding to DNA in the context of chromatin. To understand …

During mammalian neocortical development, neural stem/progenitor cells (NSCs)
sequentially give rise to deep layer neurons and superficial layer neurons through mid-to …

Glutamatergic neurons of the mammalian cerebral cortex originate from radial glia (RG)
progenitors in the ventricular zone (VZ). During corticogenesis, neuroblasts migrate toward …

Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state
through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of …

During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give
rise to different subtypes of neurons and glia via a highly orchestrated process. To …

Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

Information processing in the cerebral cortex requires the activation of diverse neurons
across layers and columns, which are established through the coordinated production of …