Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

The biosynthesis of bacterial cell wall peptidoglycan is a complex process involving many
different steps taking place in the cytoplasm (synthesis of the nucleotide precursors) and on …

Covering: 2003 to 2009 The quest for new antibiotics, especially those with activity against
Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in …

MraY (phospho-MurNAc-pentapeptide translocase) is an integral membrane enzyme that
catalyzes an essential step of bacterial cell wall biosynthesis: the transfer of the …

Antibiotics are an essential part of modern medicine. The emergence of antibiotic‐resistant
mutants among bacteria is seemingly inevitable, and results, within a few decades, in …

Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

Peptidoglycan is the major component of the cell envelope of virtually all bacteria. It has
structural roles and acts as a selective sieve for molecules from the outer environment …

Reinventing phage therapy: are the parts greater than the sum? | Nature Biotechnology
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Antibiotic-resistant bacterial infection is a serious threat to public health. Peptidoglycan
biosynthesis is a well-established target for antibiotic development. MraY (phospho-MurNAc …