Temporal lobe epilepsy-induced neurodegeneration and cognitive deficits: Implications for aging

M Vrinda, S Arun, BN Srikumar, BM Kutty… - Journal of chemical …, 2019 - Elsevier
Epilepsy is a neurological condition associated with seizures, neurodegeneration, circuit
reorganization, and other structural and functional abnormalities. These elements ultimately …

Status epilepticus triggers time-dependent alterations in microglia abundance and morphological phenotypes in the hippocampus

SK Wyatt-Johnson, SA Herr, AL Brewster - Frontiers in neurology, 2017 - frontiersin.org
Status epilepticus (SE) is defined by the occurrence of prolonged “non-stop” seizures that
last for at least 5 min. SE provokes inflammatory responses including the activation of …

Hijacking of hippocampal–cortical oscillatory coupling during sleep in temporal lobe epilepsy

RAV Mendes, LR Zacharias, RN Ruggiero, JP Leite… - Epilepsy & Behavior, 2021 - Elsevier
Memory impairment is the most common cognitive deficit in patients with temporal lobe
epilepsy (TLE). This type of epilepsy is currently regarded as a network disease because of …

Long-term effects of zinc deficiency and zinc supplementation on developmental seizure-induced brain damage and the underlying GPR39/ZnT-3 and MBP …

NN Chen, DJ Zhao, YX Sun, DD Wang… - Frontiers in …, 2019 - frontiersin.org
We previously illustrated that long-term upregulated expression of ZnT-3 in the
hippocampus of rats that underwent neonatal seizures was restored by pretreatment with a …

Antiepileptogenic effects of Anakinra, lamotrigine and their combination in a Lithium–pilocarpine model of temporal lobe epilepsy in rats

OE Zubareva, DS Sinyak, AD Kalita, AV Griflyuk… - International Journal of …, 2023 - mdpi.com
Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is
often refractory to drug therapy. A potential cause of temporal lobe epilepsy is primary brain …

[HTML][HTML] Reconfiguration dynamics of a language-and-memory network in healthy participants and patients with temporal lobe epilepsy

S Banjac, E Roger, C Pichat, E Cousin, C Mosca… - NeuroImage: Clinical, 2021 - Elsevier
Current theoretical frameworks suggest that human behaviors are based on strong and
complex interactions between cognitive processes such as those underlying language and …

Hippocampal sclerosis in pilocarpine epilepsy: survival of peptide-containing neurons and learning and memory disturbances in the adult NMRI strain mouse

A Mátyás, E Borbély, A Mihály - International Journal of Molecular …, 2021 - mdpi.com
The present experiments reveal the alterations of the hippocampal neuronal populations in
chronic epilepsy. The mice were injected with a single dose of pilocarpine. They had status …

Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology

DG Cabalo, J DeKraker, J Royer, K Xie, S Tavakol… - Brain, 2024 - academic.oup.com
Declarative memory encompasses episodic and semantic divisions. Episodic memory
captures singular events with specific spatiotemporal relationships, whereas semantic …

From adagio to allegretto: The changing tempo of theta frequencies in epilepsy and its relation to interneuron function

KA Moxon, K Shahlaie, F Girgis, I Saez, J Kennedy… - Neurobiology of …, 2019 - Elsevier
Despite decades of research, our understanding of epilepsy, including how seizures are
generated and propagate, is incomplete. However, there is growing recognition that …

[HTML][HTML] The differential effect of levetiracetam on memory and anxiety in rats

E Zwierzyńska, B Pietrzak - Epilepsy & Behavior, 2022 - Elsevier
Objective One of the newest antiseizure medication is levetiracetam (LEV). It might be
effective in various indications, not only related to convulsions. Central nervous system …