Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …

Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the
treatment of a range of diseases. Through tremendous effort, considerable knowledge has …

Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …

A library of novel bis-Schiff base derivatives based on thiobarbituric acid has been
effectively synthesized by multi-step reactions as part of our ongoing pursuit of novel anti …

In the present study, we report the discovery of a novel class of substituted 4-amino-2-
thiopyrimidines as antiangiogenic and antiproliferative agents. Structural hybridization …

BRAF is the most common serine-threonine protein kinase and regulates signal transduction
from RAS to MEK inside the cell. The BRAF is a highly active isoform of RAF kinase. BRAF …

Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease, often accompanied by obesity, diabetes, and increased risks of depression and …

Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Sorafenib,
a multikinase inhibitor, is the first-line drug approved by the Food and Drug Administration …

Background/Aim: Previously, we reported the identification of a cytotoxic chemotype
compound CC-I (1a), a derivative of thiobarbituric acid. We also reported the anticancer …

A series of twenty five new thiobarbituric acid derivatives, viz. 3a-h, 4-7, 8a-c, 9, 10a-c, 11
and 12a-d, were designed and synthesized as potential cytotoxic agents. In-vitro screening …