Uric acid and cardiovascular disease: an update from molecular mechanism to clinical perspective

W Yu, JD Cheng - Frontiers in pharmacology, 2020 - frontiersin.org
Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Uric acid in metabolic syndrome: does uric acid have a definitive role?

S Copur, A Demiray, M Kanbay - European journal of internal medicine, 2022 - Elsevier
Increased serum uric acid (SUA) levels are commonly seen in patients with metabolic
syndrome and are widely accepted as risk factors for hypertension, gout, non-alcoholic fatty …

Prevalence of hyperuricemia among Chinese adults: findings from two nationally representative cross-sectional surveys in 2015–16 and 2018–19

M Zhang, X Zhu, J Wu, Z Huang, Z Zhao… - Frontiers in …, 2022 - frontiersin.org
Objective To determine the nationwide prevalence of hyperuricemia in China and evaluate
its trends and associated risk factors. Methods Using a multi-stage, stratified, cluster …

Uric acid and hypertension: a review of evidence and future perspectives for the management of cardiovascular risk

C Borghi, D Agnoletti, AFG Cicero, E Lurbe… - Hypertension, 2022 - Am Heart Assoc
Uric acid is the final product of purine metabolism, and its increased serum levels have been
directly involved in the pathogenesis and natural history of hypertension. The relationship …

Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions

NR Pugliese, P Pellicori, F Filidei… - Cardiovascular …, 2022 - academic.oup.com
Many patients with symptoms and signs of heart failure have a left ventricular ejection
fraction≥ 50%, termed heart failure with preserved ejection fraction (HFpEF). HFpEF is a …

Hyperuricemia and risk of cardiovascular outcomes: the experience of the URRAH (uric acid right for heart health) project

A Maloberti, C Giannattasio, M Bombelli… - High Blood Pressure & …, 2020 - Springer
Abstract The latest European Guidelines of Arterial Hypertension have officially introduced
uric acid evaluation among the cardiovascular risk factors that should be evaluated in order …

Therapeutic strategies for the treatment of chronic hyperuricemia: an evidence-based update

AFG Cicero, F Fogacci, M Kuwabara, C Borghi - Medicina, 2021 - mdpi.com
This article aims to critically review the evidence on the available therapeutic strategies for
the treatment of hyperuricemia. For this reason, several papers were reviewed. Xanthine …

The key role of uric acid in oxidative stress, inflammation, fibrosis, apoptosis, and immunity in the pathogenesis of atrial fibrillation

Y Deng, F Liu, X Yang, Y Xia - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia that leads to numerous adverse
outcomes including stroke, heart failure, and death. Hyperuricemia is an important risk factor …

The results of the URRAH (Uric acid right for heart health) project: A focus on hyperuricemia in relation to cardiovascular and kidney disease and its role in metabolic …

A Maloberti, A Mengozzi, E Russo, AFG Cicero… - High Blood Pressure & …, 2023 - Springer
Abstract The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases
has already been extensively evaluated, and it was found to be an independent predictor of …

The role of uric acid in acute and chronic coronary syndromes

A Maloberti, M Biolcati, G Ruzzenenti, V Giani… - Journal of Clinical …, 2021 - mdpi.com
Uric acid (UA) is the final product of the catabolism of endogenous and exogenous purine
nucleotides. While its association with articular gout and kidney disease has been known for …