P4-ATPases, a subfamily of P-type ATPases, translocate cell membrane phospholipids from
the exoplasmic/luminal leaflet to the cytoplasmic leaflet to generate and maintain membrane …

Background: Osteoarthritis (OA) is the most prevalent chronic degenerative joint disease
among the aged population. However, current treatments for OA are limited to alleviating …

ABSTRACT TMEM16F (also known as ANO6), a Ca2+-activated lipid scramblase
(CaPLSase) that dynamically disrupts lipid asymmetry, plays a crucial role in various …

Purpose: Familial exudative vitreoretinopathy (FEVR) is a blinding retinal vascular disease.
Clinically, FEVR is characterized by incomplete vascularization of the peripheral retina and …

The processing, maturation, and secretion of insulin are under precise regulation, and
dysregulation causes profound defects in glucose handling, leading to diabetes. Tmem30a …

Despite progress in the management of patients with retinal vascular and degenerative
diseases, there is still an unmet clinical need for safe and effective therapeutic options with …

Background Phosphatidylserine is translocated to the inner leaflet of the phospholipid
bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is …

Familial exudative vitreoretinopathy (FEVR) is a severe genetic disorder characterized by
incomplete vascularization of the peripheral retina and associated symptoms that can lead …

Phosphatidylserine (PS) is distributed asymmetrically in the plasma membrane of eukaryotic
cells. Phosphatidylserine flippase (P4-ATPase) transports PS from the outer leaflet of the …

The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of
eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS …