VTA GABA neurons at the interface of stress and reward
C Bouarab, B Thompson, AM Polter - Frontiers in neural circuits, 2019 - frontiersin.org
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
γ-Aminobutyric acid (GABA) signalling in plants
The role of γ-aminobutyric acid (GABA) as a signal in animals has been documented for
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
Fused cerebral organoids model interactions between brain regions
Human brain development involves complex interactions between different regions,
including long-distance neuronal migration or formation of major axonal tracts. Different …
including long-distance neuronal migration or formation of major axonal tracts. Different …
Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors
Optimally orchestrating complex behavioral states, such as the pursuit and consumption of
food, is critical for an organism's survival. The lateral hypothalamus (LH) is a …
food, is critical for an organism's survival. The lateral hypothalamus (LH) is a …
Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows
E Pessione - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Lactic Acid Bacteria (LAB) are ancient organisms that cannot biosynthesize functional
cytochromes, and cannot get ATP from respiration. Besides sugar fermentation, they evolved …
cytochromes, and cannot get ATP from respiration. Besides sugar fermentation, they evolved …
The GABAA receptor as a therapeutic target for neurodevelopmental disorders
S Braat, RF Kooy - Neuron, 2015 - cell.com
Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …
neurodevelopmental disorders that collectively affect a significant percentage of the world …
Is there more to GABA than synaptic inhibition?
DF Owens, AR Kriegstein - Nature Reviews Neuroscience, 2002 - nature.com
In the mature brain, GABA (γ-aminobutyric acid) functions primarily as an inhibitory
neurotransmitter. But it can also act as a trophic factor during nervous system development …
neurotransmitter. But it can also act as a trophic factor during nervous system development …
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
Background Reelin (RELN) is a glycoprotein secreted preferentially by cortical γ-
aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin …
aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin …
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
MG Kaplitt, A Feigin, C Tang, HL Fitzsimons, P Mattis… - The Lancet, 2007 - thelancet.com
Background Dopaminergic neuronal loss in Parkinson's disease leads to changes in the
circuitry of the basal ganglia, such as decreased inhibitory GABAergic input to the …
circuitry of the basal ganglia, such as decreased inhibitory GABAergic input to the …