Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Thousands of mutations are identified yearly. Although many directly affect protein
expression, an increasing proportion of mutations is now believed to influence mRNA …

Splicing is the most frequently altered biological process by mutations within gene regions.
Information for splicing is recognized by several factors that bind pre‐mRNA sequence and …

Understanding the molecular mechanisms responsible for the regulation of the
transcriptome present in eukaryotic cells is one of the most challenging tasks in the …

Purpose: Stargardt disease (STGD1) is an autosomal recessive retinopathy, caused by
mutations in the retina-specific ATP-binding cassette transporter (ABCA4) gene. To establish …

Alternative splicing is a major diversification mechanism in the human transcriptome and
proteome. Several diseases, including cancers, have been associated with dysregulation of …

Background Here we present the genome sequence of Rhodotorula graminis WP1, a pink-
pigmented, encapsulated yeast strain belonging to the Basidiomycota phylum that was …

Alternative splicing (AS) enhances transcriptome plasticity and proteome diversity in
response to diverse growth and stress cues, which places AS at the crossroads of …

RNA splicing is an important aspect of gene regulation in many organisms. Splicing of RNA
is regulated by complicated mechanisms involving numerous RNA-binding proteins and the …

Background Over 60% of protein-coding genes in vertebrates express mRNAs that undergo
alternative splicing. The resulting collection of transcript isoforms poses significant …