Despite having been identified first, their greater degree of complexity has resulted in our
understanding of eukaryotic ribosomes lagging behind that of their bacterial and archaeal …

The corepressor mSin3A is the core component of a chromatin-modifying complex that is
recruited by multiple gene-specific transcriptional repressors. In order to understand the role …

In retroviruses and the double-stranded RNA totiviruses, the efficiency of programmed− 1
ribosomal frameshifting is critical for ensuring the proper ratios of upstream-encoded capsid …

During evolution, parasitic microorganisms have faced the challenges of adapting to
different environments to colonize a variety of hosts. Giardia lamblia, a common cause of …

Mitochondrial function degenerates with ageing and in ageing-related neuromuscular
degenerative diseases, causing physiological decline of the cell. Factors that can delay the …

Deacetylation of histones is carried out by a corepressor complex in which Sin3A is an
essential scaffold protein. Two proteins in this complex, the Sin3A-associated proteins …

There is accumulating evidence that many ribosomal proteins are involved in shaping rRNA
into their functionally correct conformations through RNA-protein interactions. Moreover …

Abstract 5S rRNA extends from the central protuberance of the large ribosomal subunit,
through the A-site finger, and down to the GTPase-associated center. Here, we present a …

The expression of ribosomal protein genes is coordinately regulated in bacteria, yeast, and
vertebrates, so that equimolar amounts of ribosomal proteins accumulate for assembly into …

Histone acetylation plays a key role in the regulation of gene expression. The chromatin
structure and accessibility of genes to transcription factors is regulated by enzymes that …