Objectives A systematic review was conducted to explore the immunogenicity of biologic
agents across inflammatory diseases and its potential impact on efficacy/safety. Methods …

Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the
gastrointestinal tract. Treatment options include biologic therapies; however, a proportion of …

We examined the assay formats used to detect anti-drug antibodies (ADA) in clinical studies
of the anti-tumour necrosis factor (TNF) monoclonal antibodies adalimumab and infliximab …

Objectives: Infliximab (IFX), a monoclonal antibody directed against tumor necrosis factor
alpha is a potent treatment option for inflammatory bowel disease (IBD). Dosing regimens in …

Background Anti–tumor necrosis factor alpha (TNFα) therapy is effective in pediatric patients
with inflammatory bowel disease (IBD) but associated with a risk of developing anti-drug …