With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and
mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

With some advances in modern medicine (such as cancer chemotherapy, broad exposure to
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …

Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in
catalysis, cell signaling, and morphogenesis. Complete monospanning protein structures …

Azoles have been applied widely to combat pathogenic fungi in medicine and agriculture
and, consequently, loss of efficacy has occurred in populations of some species. Often, but …

Infections by fungal pathogens such as Candida albicans and Aspergillus fumigatus and
their resistance to triazole drugs are major concerns. Fungal lanosterol 14α-demethylase …

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and
treatments for superficial and disseminated fungal infections, but cure rates are not optimal …

Aspergillus fumigatus is the opportunistic fungal pathogen that predominantly affects the
immunocompromised population and causes 600,000 deaths/year. The cytochrome P450 …

Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …