In this Tutorial Review, we make the point that a true understanding of trends in reactivity (as
opposed to measuring or simply computing them) requires a causal reactivity model. To this …

Recent developments in experimental and computational chemistry have identified a rapidly
growing class of nucleophilic aromatic substitutions that proceed by concerted (cSNAr) …

Nucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes
in pharmaceutical and chemical research, providing a broadly useful platform for the …

This book provides a comprehensive overview of nucleophilic aromatic substitutions,
focusing on the mechanistic and synthetic features that govern these reactions. The first …

Nucleophilic aromatic substitution (SNAr) is widely used by organic chemists to functionalize
aromatic molecules, and it is the most commonly used method to generate arenes that …

Molecular imaging has witnessed an upsurge in growth, with positron emission tomography
leading the way. This trend has encouraged numerous synthetic chemists to enter the field …

The concept of aromaticity was initially introduced in chemistry to account for the stability,
reactivity, molecular structures, and other properties of many unsaturated organic …

Fluorochemicals are a widely distributed class of compounds and have been utilized across
a wide range of industries for decades. Given the environmental toxicity and adverse health …

This Glossary contains definitions, explanatory notes, and sources for terms used in physical
organic chemistry. Its aim is to provide guidance on the terminology of physical organic …

Meisenheimer's missing! Anionic σ-complexes, best known as Meisenheimer complexes,
have long been assumed to be intermediates in SN Ar reactions. New evidence now …