Effects of inflammation on myopia: evidence and potential mechanisms

R Xu, J Zheng, L Liu, W Zhang - Frontiers in Immunology, 2023 - frontiersin.org
As the most common type of refractive error, myopia has become one of the leading causes
of visual impairment. With the increasing prevalence of myopia, there is a growing need to …

Applications of genomics and transcriptomics in precision medicine for myopia control or prevention

L Jiang, DX Goh, JHZ Koh, X Chan, NA Brennan… - Biomolecules, 2023 - mdpi.com
Myopia is a globally emerging concern accompanied by multiple medical and socio-
economic burdens with no well-established causal treatment to control thus far. The study of …

[HTML][HTML] Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia

J Feng, X Chen, R Li, Y Xie, X Zhang, X Guo, L Zhao… - Iscience, 2024 - cell.com
The biological mechanisms underlying the development of myopia have not yet been
completely elucidated. The retina is critical for visual signal processing, which primarily …

[HTML][HTML] Metabolic characterization of human intraocular fluid in patients with pathological myopia

P Lian, X Zhao, H Song, S Tanumiharjo, J Chen… - Experimental Eye …, 2022 - Elsevier
Pathological myopia (PM) and its associated complications can lead to permanent vision
loss. However, the cellular mechanisms underlying PM development remain unclear. To …

Higher circulating levels of neutrophils and basophils are linked to myopic retinopathy

J Qi, W Pan, T Peng, L Zeng, X Li, Z Chen… - International journal of …, 2022 - mdpi.com
This retrospective study investigated circulating immune cell alteration in patients with
myopic retinopathy. Blood test results and demographic and ocular information of 392 …

Exploring the relationship between intestinal flora and the pathological mechanism of myopia in adolescents from the perspective of Chinese and Western medicine: a …

X Xi, L Han, M Ding, J Li, C Qiao, Z Liu, S Qie - Medicine, 2023 - journals.lww.com
The etiology of adolescent myopia involves genetic and environmental factors. The
pathological mechanism of modern medicine includes blood perfusion, changes in blood …

Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway

B Bao, J Liu, T Li, Z Yang, G Wang, J Xin, H Bi… - Archives of Biochemistry …, 2023 - Elsevier
Objective This study aimed to investigate the regulatory role of the PI3K/AKT/ERK signaling
pathway in retinal fibrosis in− 6.0 diopter (D) lens-induced myopic (LIM) guinea pigs …

RNA-Sequencing Analysis Reveals the Role of Mitochondrial Energy Metabolism Alterations and Immune Cell Activation in Form-Deprivation and Lens-Induced …

H Kim, W Lee, YA Kim, S Yu, J Jeong, Y Choi, Y Lee… - Genes, 2023 - mdpi.com
Myopia is a substantial global public health concern primarily linked to the elongation of the
axial length of the eyeball. While numerous animal models have been employed to …

LncRNA-XR_002792574. 1-mediated ceRNA network reveals potential biomarkers in myopia-induced retinal ganglion cell damage

X Wang, Q Lin, S Liu, X Li, X Kong, Y Wang… - Journal of Translational …, 2023 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) play a key role in the occurrence
and progression of myopia. However, the function of lncRNAs in retinal ganglion cells …

Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy

L Zeng, Z Yang, W Pan, D Lin, Y Tang… - Journal of …, 2024 - Taylor & Francis
Purpose In this study, we aimed to investigate the relationship between the intraocular levels
of inflammatory factors and myopia-related retinal vascular and neuronal degeneration …