MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in
biological processes spanning from early developmental stages to the intricate process of …

Cell state transitions are prevalent in biology, playing a fundamental role in development,
homeostasis and repair. Dysregulation of cell state transitions can lead to or occur in a wide …

Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate
movements. In vertebrates, the molecular identities of the cardinal MN types such as those …

Periodic gene expression dynamics are key to cell and organism physiology. Studies of
oscillatory expression have focused on networks with intuitive regulatory negative feedback …

Organisms utilize gene regulatory networks (GRN) to make fate decisions, but the regulatory
mechanisms of transcription factors (TF) in GRNs are exceedingly intricate. A longstanding …

The ability to express transgenes at specified levels is critical for understanding cellular
behaviors, and for applications in gene and cell therapy. Transfection, viral vectors, and …

Understanding self-organized pattern formation is fundamental to biology. In 1952, Alan
Turing proposed a pattern-enabling mechanism in reaction-diffusion systems containing …

Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by the
selective loss of spinal motor neurons (MNs) and concomitant muscle weakness. Mutation of …

MicroRNAs are extensively known for post-transcriptional gene regulation and pattern
formation in the embryonic developmental stage. We explore the origin of these spatio …

Multiple intermediate epithelial-mesenchymal transition (EMT) states reflecting hybrid
epithelial and mesenchymal phenotypes were observed in physiological and pathological …