Childhood trauma is a potent risk factor for developing depression in adulthood, particularly
in response to additional stress. We here summarize results from a series of clinical studies …

The measurement of cortisol in saliva provides the basic scientist as well as the clinician
with a reliable tool for investigations of hypothalamus-pituitary-adrenal axis activity. Since …

Objective Results from animal and human studies suggest that disregulations of the
hypothalamus-pituitary-adrenal (HPA) axis are involved in several behavioral, circulatory …

* Corresponding author. Tel.:+ 49 651 201 2981; fax:+ 49 651 201 3690. E-mail address:
kudielka@ uni-trier. de (BM Kudielka). 0301-0511/$–see front matter© 2004 Elsevier BV All …

Stress precipitates depression and alters its natural history. Major depression and the stress
response share similar phenomena, mediators and circuitries. Thus, many of the features of …

This study takes advantage of continuing advances in the precision of magnetic resonance
imaging (MRI) to quantify hippocampal volumes in a series of human subjects with a history …

The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the
hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major …

The cerebral distribution of CRF and binding sites for CRF..............................................................
.......................... 2.1. The cerebral distribution of CRF …

BACKGROUND: While there is evidence to suggest that major depressive disorder (MDD) is
associated with structural brain abnormalities, the precise nature of these abnormalities …

Depression is a major cause of disability worldwide, but we know little about the underlying
fundamental biology. Research is hindered by the difficulties of modelling a disorder of …