Organization of neural circuits underlying social behavior: a consideration of the medial amygdala

T Raam, W Hong - Current opinion in neurobiology, 2021 - Elsevier
The medial amygdala (MeA) is critical for the expression of a broad range of social
behaviors, and is also connected to many other brain regions that mediate those same …

Neural circuits of social behaviors: Innate yet flexible

D Wei, V Talwar, D Lin - Neuron, 2021 - cell.com
Social behaviors, such as mating, fighting, and parenting, are fundamental for survival of any
vertebrate species. All members of a species express social behaviors in a stereotypical and …

An approximate line attractor in the hypothalamus encodes an aggressive state

A Nair, T Karigo, B Yang, S Ganguli, MJ Schnitzer… - Cell, 2023 - cell.com
The hypothalamus regulates innate social behaviors, including mating and aggression.
These behaviors can be evoked by optogenetic stimulation of specific neuronal …

A hypothalamic pathway that suppresses aggression toward superior opponents

D Wei, T Osakada, Z Guo, T Yamaguchi… - Nature …, 2023 - nature.com
Aggression is costly and requires tight regulation. Here we identify the projection from
estrogen receptor alpha-expressing cells in the caudal part of the medial preoptic area …

Hypothalamic control of innate social behaviors

L Mei, T Osakada, D Lin - Science, 2023 - science.org
Sexual, parental, and aggressive behaviors are central to the reproductive success of
individuals and species survival and thus are supported by hardwired neural circuits. The …

Periaqueductal gray neurons encode the sequential motor program in hunting behavior of mice

H Yu, X Xiang, Z Chen, X Wang, J Dai, X Wang… - Nature …, 2021 - nature.com
Sequential encoding of motor programs is essential for behavior generation. However,
whether it is critical for instinctive behavior is still largely unknown. Mouse hunting behavior …

Neural dynamics in the limbic system during male social behaviors

Z Guo, L Yin, V Diaz, B Dai, T Osakada, JE Lischinsky… - Neuron, 2023 - cell.com
Sexual and aggressive behaviors are vital for species survival and individual reproductive
success. Although many limbic regions have been found relevant to these behaviors, how …

A line attractor encoding a persistent internal state requires neuropeptide signaling

G Mountoufaris, A Nair, B Yang, DW Kim, A Vinograd… - Cell, 2024 - cell.com
Internal states drive survival behaviors, but their neural implementation is poorly understood.
Recently, we identified a line attractor in the ventromedial hypothalamus (VMH) that …

Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice

K Inada, M Hagihara, K Tsujimoto, T Abe, A Konno… - Neuron, 2022 - cell.com
The adult brain can flexibly adapt behaviors to specific life-stage demands. For example,
while sexually naive male mice are aggressive to the conspecific young, they start to provide …

A dedicated hypothalamic oxytocin circuit controls aversive social learning

T Osakada, R Yan, Y Jiang, D Wei, R Tabuchi, B Dai… - Nature, 2024 - nature.com
To survive in a complex social group, one needs to know who to approach and, more
importantly, who to avoid. In mice, a single defeat causes the losing mouse to stay away …