Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection

L Pardo-López, M Soberón… - FEMS microbiology …, 2013 - academic.oup.com
Bacillus thuringiensis bacteria are insect pathogens that produce different Cry and Cyt toxins
to kill their hosts. Here we review the group of three-domain Cry (3d-Cry) toxins. Expression …

Bacillus thuringiensis: a story of a successful bioinsecticide

A Bravo, S Likitvivatanavong, SS Gill… - Insect biochemistry and …, 2011 - Elsevier
Bacillus thuringiensis (Bt) bacteria are insect pathogens that rely on insecticidal pore
forming proteins known as Cry and Cyt toxins to kill their insect larval hosts. At least four …

Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control

A Bravo, SS Gill, M Soberón - Toxicon, 2007 - Elsevier
Bacillus thuringiensis Crystal (Cry) and Cytolitic (Cyt) protein families are a diverse group of
proteins with activity against insects of different orders—Lepidoptera, Coleoptera, Diptera …

Diversity of Bacillus thuringiensis crystal toxins and mechanism of action

MJ Adang, N Crickmore, JL Jurat-Fuentes - Advances in insect physiology, 2014 - Elsevier
Parasporal crystals produced by Bacillus thuringiensis (Bt) bacteria are the main virulence
factors underlying Bt toxicity to insects. Parasporal crystals are composed primarily of Cry …

Role of Receptors in Bacillus thuringiensis Crystal Toxin Activity

CR Pigott, DJ Ellar - Microbiology and molecular biology reviews, 2007 - Am Soc Microbiol
Bacillus thuringiensis produces crystalline protein inclusions with insecticidal or nematocidal
properties. These crystal (Cry) proteins determine a particular strain's toxicity profile …

How to cope with insect resistance to Bt toxins?

A Bravo, M Soberón - Trends in biotechnology, 2008 - cell.com
Transgenic Bt crops producing insecticidal crystalline proteins from Bacillus thuringiensis, so-
called Cry toxins, have proved useful in controlling insect pests. However, the future of Bt …

Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin

I Arenas, A Bravo, M Soberón, I Gómez - Journal of biological chemistry, 2010 - ASBMB
Cry toxins produced by Bacillus thuringiensis have been recognized as pore-forming toxins
whose primary action is to lyse midgut epithelial cells in their target insect. In the case of the …

Reduced Levels of Membrane-Bound Alkaline Phosphatase Are Common to Lepidopteran Strains Resistant to Cry Toxins from Bacillus thuringiensis

JL Jurat-Fuentes, L Karumbaiah, SRK Jakka, C Ning… - PLoS …, 2011 - journals.plos.org
Development of insect resistance is one of the main concerns with the use of transgenic
crops expressing Cry toxins from the bacterium Bacillus thuringiensis. Identification of …

Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a “ping pong” binding mechanism with Manduca sexta aminopeptidase-N and cadherin receptors

S Pacheco, I Gómez, I Arenas, G Saab-Rincon… - Journal of biological …, 2009 - ASBMB
Bacillus thuringiensis Cry toxins are used worldwide as insecticides in agriculture, in
forestry, and in the control of disease transmission vectors. In the lepidopteran Manduca …

Bacillus thuringiensis Cry1A toxins are versatile proteins with multiple modes of action: two distinct pre-pores are involved in toxicity

I Gómez, J Sánchez, C Muñoz-Garay… - Biochemical …, 2014 - portlandpress.com
Cry proteins from Bacillus thuringiensis are insecticidal PFTs (pore-forming toxins). In the
present study, we show that two distinct functional pre-pores of Cry1Ab are formed after …