About 280 million people suffer from depression as the most common neurological disorder
and the most common cause of death worldwide. Exercise with serotonin released in the …

Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Chronic insomnia disorder, which affects 6–10% of the population, is diagnostically
characterized by ongoing difficulties with initiating or maintaining sleep occurring at least …

The circadian clock provides cue-independent anticipatory signals for diurnal rhythms of
baseline glucose levels and glucose tolerance. The central circadian clock is located in the …

Mood disorders are amongst the most prevalent and severe disorders worldwide, with a
tendency to be recurrent and disabling. Although multiple mechanisms have been …

The self is experienced differently in depression. It is infused with pervasive low mood, and
structured by negative self-related thoughts. The concept of the self has been difficult to …

Post-traumatic stress disorder (PTSD) is a trauma-related condition that produces
distressing fear memory intrusions, avoidance behaviors, hyperarousal/startle, stress …

Insomnia disorder is considered as a stress‐related disorder associated with hyperarousal,
stress and emotion dysregulation and the instability of the 'flip‐flop'switch system. The …

Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding
behavior and the sleep and wakefulness states. Since their discovery, several lines of …

Orexin plays a significant role in the modulation of REM sleep, as well as in the regulation of
appetite and feeding. This review explores, first, the current evidence on the role of orexin in …