GRP78 at the centre of the stage in cancer and neuroprotection

C Casas - Frontiers in neuroscience, 2017 - frontiersin.org
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a
multifunctional protein with activities far beyond its well-known role in the unfolded protein …

Protein–protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches

AG Ngounou Wetie, I Sokolowska, AG Woods… - Cellular and molecular …, 2014 - Springer
Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

Investigation of stable and transient protein–protein interactions: past, present, and future

AG Ngounou Wetie, I Sokolowska, AG Woods… - …, 2013 - Wiley Online Library
This article presents an overview of the literature and a review of recent advances in the
analysis of stable and transient protein–protein interactions (PPI s) with a focus on their …

A pilot proteomic analysis of salivary biomarkers in autism spectrum disorder

AG Ngounou Wetie, KL Wormwood, S Russell… - Autism …, 2015 - Wiley Online Library
Autism spectrum disorder (ASD) prevalence is increasing, with current estimates at 1/68–
1/50 individuals diagnosed with an ASD. Diagnosis is based on behavioral assessments …

Unfolded protein response as a therapeutic target in cardiovascular disease

G Zhang, X Wang, TG Gillette, Y Deng… - Current topics in …, 2019 - ingentaconnect.com
Cardiovascular disease is the leading cause of death worldwide. Despite overwhelming
socioeconomic impact and mounting clinical needs, our understanding of the underlying …

A peptide derived from phage display library exhibits anti-tumor activity by targeting GRP78 in gastric cancer multidrug resistance cells

J Kang, G Zhao, T Lin, S Tang, G Xu, S Hu, Q Bi, C Guo… - Cancer letters, 2013 - Elsevier
Multidrug resistance (MDR) remains a significant challenge to the clinical treatment of
gastric cancer (GC). In the present study, using a phage display approach combined with …

Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors

J Mandelin, M Cardó-Vila… - Proceedings of the …, 2015 - National Acad Sciences
We performed combinatorial peptide library screening in vivo on a novel human prostate
cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in …

Comparative two‐dimensional polyacrylamide gel electrophoresis of the salivary proteome of children with autism spectrum disorder

AG Ngounou Wetie, KL Wormwood… - Journal of cellular …, 2015 - Wiley Online Library
In the last decades, prevalence of autism spectrum disorder (ASD) has been on the rise.
However, clear aetiology is still elusive and improvements in early diagnosis are needed. To …

Cancer secretomes and their place in supplementing other hallmarks of cancer

S Patel, AGN Wetie, CC Darie, BD Clarkson - Advancements of mass …, 2014 - Springer
The secretome includes all macromolecules secreted by cells, in particular conditions at
defined times, allowing cell–cell communication. Cancer cell secretomes that are altered …

Salivary proteomics and biomarkers in neurology and psychiatry

KL Wormwood, R Aslebagh… - PROTEOMICS …, 2015 - Wiley Online Library
Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective
and earlier diagnoses of CNS conditions. Proteomics and other omics MS‐based …